C6427

Clindamycin-2-Phosphat

Name: Clindamycin-2-Phosphat
Brand: SIGMA

aminoglycoside antibiotic

Synonym(e):

Clindamycin-2-dihydrogenphosphat

Slide 1 of 3

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Über diesen Artikel

Empirische Formel (Hill-System):

C₁₈H₃₄ClN₂O₈PS

CAS-Nummer:

24729-96-2

Molekulargewicht:

504.96

NACRES:

NA.76

PubChem Substance ID:

24892866

UNSPSC Code:

51102829

EC Number:

246-433-0

MDL number:

MFCD07793328

Wichtige Dokumente

Gesamtdokumentation anzeigen

Fortfahren mit

Technischer Dienst

Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.

Unterstützung erhalten

Quality Level

100

form

solid

solubility

DMSO: 224 mg/mL at 25 °C

antibiotic activity spectrum

Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC([C@H](C)Cl)C2O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O

InChI

1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12?,13+,14-,15?,16+,18+/m0/s1

InChI key

UFUVLHLTWXBHGZ-MWBQRTRKSA-N

Ähnliche Artikel vergleichen

Vollständigen Vergleich anzeigen

Unterschiede anzeigen

1 of 4

Dieser Artikel	C5269	L6004	62143
Sigma-Aldrich C6427 Clindamycin 2-phosphate	Sigma-Aldrich C5269 Clindamycin hydrochloride	Sigma-Aldrich L6004 Lincomycin hydrochloride	Sigma-Aldrich 62143 Lincomycin hydrochloride
mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes
antibiotic activity spectrum Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-positive bacteria	antibiotic activity spectrum Gram-positive bacteria
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
form solid	form powder or crystals	form -	form powder or crystals
solubility DMSO: 224 mg/mL at 25 °C	solubility H₂O: 50 mg/mL	solubility H₂O: soluble 50 mg/mL	solubility H₂O: 50 mg/mL, clear, colorless to faintly yellow
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

General description

Chemical structure: macrolide

Application

Clindamycin 2-phosphate is an aminoglycoside antibiotic that has been used to study the cytoxicity of antibiotics on human cell lines [1], Bacterial protein synthesis and peptide translation, and the inhibition of human Tyrosyl-DNA Phosphodiesterase [2].

Biochem/physiol Actions

Wirkungsspektrum: Gram-positive Kokken und Taxoplasma. Besonders aktiv gegen anaerobe Bakterien.
Wirkmechanismus: Hemmt die Proteinsynthese in Bakterien durch Bindung der 50S ribosomalen Untereinheit

Clindamycin 2-phosphate is a pharmacological tyrosyl-DNA phosphodiesterase (Tdp1) inhibitor. Clindamycin 2-phosphate can repair DNA topoisomerase I-DNA covalent complexes by hydrolyzing the tyrosyl-DNA bond. It inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit. [2]. Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.

Other Notes

Antibakterielles und antiprotozoales Antibiotikum der Lincosamid-Klasse.

Keep container tightly closed in a dry and well-ventilated place.

pictograms

GHS07

signalword

Warning

hcodes

H302,H317,H319,H362

pcodes

P260 - P263 - P280 - P301 + P312 - P302 + P352 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Sens. 1

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

107H1159V

107H1159

047F07202

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Suche nach COA

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors.

Zhiyong Liao et al.

Molecular pharmacology, 70(1), 366-372 (2006-04-19)

DNA topoisomerase I (Top1) is the target of camptothecin, and novel Top1 inhibitors are in development as anticancer agents. Top1 inhibitors damage DNA by trapping covalent complexes between the Top1 catalytic tyrosine and the 3'-end of the broken DNA. Tyrosyl-DNA

Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris.

L Babayeva et al.

Journal of the European Academy of Dermatology and Venereology : JEADV, 25(3), 328-333 (2010-07-30)

No single effective topical treatment is available for treating all pathogenic factors causing acne vulgaris (AV). Salicylic acid (SA), tretinoin (all-TRA) and clindamycin phosphate (CDP) are known to to be effective agents depending on their comedolytic and anti-inflammatory properties. To

Assemblage of drug release modules: effect of module shape and position in the assembled systems on floating behavior and release rate.

C Hascicek et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 77(1), 116-121 (2010-11-23)

The aim of this work was to study the clindamycin release kinetics from floating delivery systems consisting of two modules assembled in void configuration, according to the modified release technology platform known as Dome Matrix®. Two modules differently shaped, i.e.

Separation and characterization of clindamycin phosphate and related impurities in injection by liquid chromatography/electrospray ionization mass spectrometry.

Shao-Min Wang et al.

Rapid communications in mass spectrometry : RCM, 23(6), 899-906 (2009-02-18)

A simple high-performance liquid chromatography/electrospray ionization tandem mass spectrometric (HPLC/ESI-MS/MS) method has been developed for the rapid identification of clindamycin phosphate and its degradation products or related impurities in clindamycin phosphate injection. Detection was performed by quadrupole time-of-flight mass spectrometry

Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: a randomized control trial.

Mohammad Ali NilFroushzadeh et al.

Indian journal of dermatology, venereology and leprology, 75(3), 279-282 (2009-05-15)

Acne vulgaris is a common skin disease that affects 85% to 100% of people at some time during their lives. It is characterized by noninflammatory follicular papules or comedones and by inflammatory papules, pustules, and nodules in its more severe

Alle zugehörigen Dokumente anzeigen

Global Trade Item Number

SKU	GTIN
C6427-100MG	04061833511206
C6427-50MG	04061833511213

Questions

Reviews

No rating value

Active Filters

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung