C6427

Clindamycin-2-Phosphat

aminoglycoside antibiotic

• Synonym(e): Clindamycin-2-dihydrogenphosphat
• Empirische Formel (Hill-System): C₁₈H₃₄ClN₂O₈PS
• CAS-Nummer: 24729-96-2
• Molekulargewicht: 504.96
• NACRES: NA.76
• PubChem Substance ID: 24892866
• UNSPSC Code: 51102829
• EC Number: 246-433-0
• MDL number: MFCD07793328

Eigenschaften

• Quality Segment: 100
• form: solid
• solubility: DMSO: 224 mg/mL at 25 °C
• antibiotic activity spectrum: Gram-positive bacteria
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC([C@H](C)Cl)C2O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O
• InChI: 1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12?,13+,14-,15?,16+,18+/m0/s1
• InChI key: UFUVLHLTWXBHGZ-MWBQRTRKSA-N

Beschreibung

General description

Chemical structure: macrolide

Application

Clindamycin 2-phosphate is an aminoglycoside antibiotic that has been used to study the cytoxicity of antibiotics on human cell lines [1], Bacterial protein synthesis and peptide translation, and the inhibition of human Tyrosyl-DNA Phosphodiesterase [2].

Biochem/physiol Actions

Wirkungsspektrum: Gram-positive Kokken und Taxoplasma. Besonders aktiv gegen anaerobe Bakterien.
Wirkmechanismus: Hemmt die Proteinsynthese in Bakterien durch Bindung der 50S ribosomalen Untereinheit

Clindamycin 2-phosphate is a pharmacological tyrosyl-DNA phosphodiesterase (Tdp1) inhibitor. Clindamycin 2-phosphate can repair DNA topoisomerase I-DNA covalent complexes by hydrolyzing the tyrosyl-DNA bond. It inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit. [2]. Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.

Other Notes

Antibakterielles und antiprotozoales Antibiotikum der Lincosamid-Klasse.

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H317,H319,H362
• pcodes: P260 - P263 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Sens. 1
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves