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C4992

Sigma-Aldrich

Carboxyatractyloside potassium salt

≥98% (HPLC), from Xanthium sibiricum, solid

Synonym(e):

C-ATR, CAT

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About This Item

Empirische Formel (Hill-System):
C31H46O18S2 · xK+
CAS-Nummer:
77228-71-8
Molekulargewicht:
770.82 (free acid basis)
UNSPSC-Code:
12352200

Biologische Quelle

Xanthium sibiricum

Assay

≥98% (HPLC)

Form

solid

Optische Aktivität

[α]/D -34 to -48°, c = 0.5 in water

Lagerbedingungen

desiccated

Farbe

white

Löslichkeit

H2O: ≥10 mg/mL

Lagertemp.

−20°C

Anwendung

Carboxyatractyloside potassium salt has been used as an activator of Ca2+-induced mPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) opening.[1][2] It has also been used as a adenine nucleotide translocator (ANT) inhibitor to study the inhibition of oxidative phosphorylation in intact T98G glioma cells.[3]

Biochem./physiol. Wirkung

Carboxyatractyloside is a highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carrier; i.e. adenine nucleotide translocase (ANT); causes stabilization of the c conformation of ANT leading to permeability transition pore (PTP) opening, loss of mitochondrial membrane potential, and apoptosis.

Leistungsmerkmale und Vorteile

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
096M4766V
105M4762V
104M4749V
101M4723V
110M4717

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The regulator of calcineurin 1 increases adenine nucleotide translocator 1 and leads to mitochondrial dysfunctions
Jiang H, et al.
Journal of Neurochemistry, 140(2), 307-319 (2017)
Underestimation of the maximal capacity of the mitochondrial electron transport system in oligomycin-treated cells
Ruas J S, et al.
PLoS ONE, 11(3), e0150967-e0150967 (2016)
Juliana S Ruas et al.
PloS one, 11(3), e0150967-e0150967 (2016-03-08)
The maximal capacity of the mitochondrial electron transport system (ETS) in intact cells is frequently estimated by promoting protonophore-induced maximal oxygen consumption preceded by inhibition of oxidative phosphorylation by oligomycin. In the present study, human glioma (T98G and U-87MG) and
Chen Zhang et al.
Scientific reports, 7, 44708-44708 (2017-03-21)
Mitochondria are intracellular organelles involved in cell survival and death, and dysfunctions of mitochondria are related to neurodegenerative diseases. As the most abundant protein in the mitochondrial inner membrane, adenine nucleotide translocator 1 (ANT1) plays a critical role in mitochondrial
N Senoo et al.
Science advances, 6(35), eabb0780-eabb0780 (2020-09-15)
The phospholipid cardiolipin has pleiotropic structural and functional roles that are collectively essential for mitochondrial biology. Yet, the molecular details of how this lipid supports the structure and function of proteins and protein complexes are poorly understood. To address this
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