C4992

Carboxyatractyloside potassium salt

≥98% (HPLC), from Xanthium sibiricum, solid

• Synonym(e): C-ATR, CAT
• Empirische Formel (Hill-System): C₃₁H₄₆O₁₈S₂ · xK⁺
• CAS-Nummer: 77228-71-8
• Molekulargewicht: 770.82 (free acid basis)
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Eigenschaften

• biological source: Xanthium sibiricum
• assay: ≥98% (HPLC)
• form: solid
• optical activity: [α]/D -34 to -48°, c = 0.5 in water
• storage condition: desiccated
• color: white
• solubility: H₂O: ≥10 mg/mL
• storage temp.: −20°C

Beschreibung

Application

Carboxyatractyloside potassium salt has been used as an activator of Ca²⁺-induced mPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) opening. It has also been used as a adenine nucleotide translocator (ANT) inhibitor to study the inhibition of oxidative phosphorylation in intact T98G glioma cells.

Biochem/physiol Actions

Carboxyatractyloside is a highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carrier; i.e. adenine nucleotide translocase (ANT); causes stabilization of the c conformation of ANT leading to permeability transition pore (PTP) opening, loss of mitochondrial membrane potential, and apoptosis.

Features and Benefits

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Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311 + H331
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges