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C3865

Sigma-Aldrich

Anti-N-Cadherin antibody, Mouse monoclonal

clone GC-4, purified from hybridoma cell culture

Synonym(e):

Anti-A-CAM, Anti-A-Cell Adhesion Molecule

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About This Item

MDL-Nummer:
MFCD00164511
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

GC-4, monoclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 135 kDa

Speziesreaktivität

chicken, monkey, mouse, human, rabbit, rat

Methode(n)

electron microscopy: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections
western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts

Isotyp

IgG1

UniProt-Hinterlegungsnummer

P19022

Anwendung(en)

research pathology

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CDH2(1000)
mouse ... Cdh2(12558)
rat ... Cdh2(83501)

Verwandte Kategorien

Allgemeine Beschreibung

N-Cadherin is a member of the cadherin family of proteins that mediate cell-cell adhesion in a calcium dependent manner. N-cadherin is a transmembrane glycoprotein that localizes in the cell-cell adherens junction on the plasma membrane. The protein is known to be localized in the cell membrane.

Anwendung

Anti-N-Cadherin antibody is suitable for the following procedures:
  • electron microscopy
  • flow cytometry
  • immunocytochemistry
  • immunohistochemistry at a concentration of 10-20μg/mL using rat cardiac muscle frozen sections
  • western blot at a concentration of 10-20μg/mL using chicken cardiac muscle or COS-7 cell extracts

Biochem./physiol. Wirkung

CDH11 gene encodes a type II classical cadherin that mediate calcium-dependent cell-cell adhesion.
Higher expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system, and ovary. Loss of expression of the gene was observed in adrenocortical carcinoma.

Physikalische Form

0.2 μm-filtered solution in 0.01 M phosphate buffered saline, pH 7.4.

Sonstige Hinweise

Clone GC-4 is also known as GB-9.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Priscilla Y Hwang et al.
Cellular and molecular bioengineering, 8(1), 51-62 (2015-04-08)
Juvenile nucleus pulposus (NP) cells of the intervertebral disc (IVD) are large, vacuolated cells that form cell clusters with strong cell-cell interactions. With maturation and aging, NP cells lose their ability to form these cell clusters, with aging-associated changes in
Priscilla Y Hwang et al.
Scientific reports, 6, 28038-28038 (2016-06-14)
Nucleus pulposus (NP) cells of the intervertebral disc are essential for synthesizing extracellular matrix that contributes to disc health and mechanical function. NP cells have a unique morphology and molecular expression pattern derived from their notochordal origin, and reside in
Rongbin Ge et al.
Oncotarget, 6(30), 28973-28987 (2015-09-12)
Metformin has emerged as a potential anticancer agent. Here, we demonstrate that metformin plays an anti-tumor role via repressing N-cadherin, independent of AMPK, in wild-type N-cadherin cancer cells. Ectopic-expression of N-cadherin develops metformin-resistant cancer cells, while suppression of N-cadherin sensitizes
Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface.
Nelson ER, et al.
Oncotarget, 7(51), 84030-84030 (2016)
Emilie Duchalais et al.
Cellular and molecular gastroenterology and hepatology, 5(1), 31-49 (2017-12-01)
In several types of cancers, tumor cells invade adjacent tissues by migrating along the resident nerves of the tumor microenvironment. This process, called perineural invasion, typically occurs along extrinsic nerves, with Schwann cells providing physical guidance for the tumor cells.
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