C124

β-CFT naphthalenedisulfonate monohydrate

solid

• Synonym(e): (−)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate monohydrate, WIN 35,428 naphthalenedisulfonate monohydrate
• Empirische Formel (Hill-System): C₁₆H₂₀FNO₂ · C₁₀H₈O₆S₂ · H₂O
• CAS-Nummer: 77210-32-3
• Molekulargewicht: 583.65
• NACRES: NA.77
• PubChem Substance ID: 24892389
• UNSPSC Code: 12352200
• MDL number: MFCD11044874
• Form: solid
• Quality level: 100

Eigenschaften

• form: solid
• Quality Level: 100
• optical activity: [α]25/D −62.5°, c = 1.0 in H₂O(lit.)
• drug control: USDEA Schedule II
• color: white
• solubility: H₂O: soluble
• storage temp.: 2-8°C
• SMILES string: O.OS(=O)(=O)c1cccc2c(cccc12)S(O)(=O)=O.COC(=O)[C@@H]3C4CCC(C[C@@H]3c5ccc(F)cc5)N4C
• InChI: 1S/C16H20FNO2.C10H8O6S2.H2O/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10;11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16;/h3-6,12-15H,7-9H2,1-2H3;1-6H,(H,11,12,13)(H,14,15,16);1H2/t12-,13+,14+,15-;;/m0../s1
• InChI key: XSJPWVYASBDEJI-YEVYTSHMSA-N

Beschreibung

Biochem/physiol Actions

Cocaine analog that inhibits the dopamine, norepinephrine, and serotonin transporters with K_is of 26.1 nM, 31.9 nM, and 127 nM, respectively. [¹¹C]-β-CFT and [¹⁸F]-β-CFT are ligands for PET imaging of the dopamine transporter in vivo.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H310 + H330,H317,H361
• pcodes: P202 - P260 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - Skin Sens. 1
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges