Wichtige Dokumente

Gesamtdokumentation anzeigen

Fortfahren mit

C1119

Caroverine hydrochloride

Name: Caroverine hydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonym(e):

1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone monohydrochloride

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Über diesen Artikel

Empirische Formel (Hill-System):

C₂₂H₂₈ClN₃O₂

CAS-Nummer:

55750-05-5

Molekulargewicht:

401.93

UNSPSC Code:

12352200

PubChem Substance ID:

329774856

MDL number:

MFCD01684929

Assay:

≥98% (HPLC)

Form:

solid

Dieses Produkt wurde eingestellt. Setzen Sie sich mit dem technischen Dienst in Verbindungzur Unterstützung

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Cl.CCN(CC)CCN1C(=O)C(Cc2ccc(OC)cc2)=Nc3ccccc13

InChI

1S/C22H27N3O2.ClH/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17;/h6-13H,4-5,14-16H2,1-3H3;1H

InChI key

JRNWTJUIMRLKBV-UHFFFAOYSA-N

Biochem/physiol Actions

Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist.

Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist. Also, Caroverine hydrochloride is a class B calcium-channel-blocker, antiglutamatergic agent, and acts as an antioxidant when administered to lab animals.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Lagerklasse

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

058K4601

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Suche nach COA

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Caroverine, a multifunctional drug with antioxidant functions.

Hans Nohl et al.

BioFactors (Oxford, England), 19(1-2), 79-85 (2004-02-06)

Here we show that lipid peroxidation of liposomal membranes was suppressed in the presence of Caroverine, a spasmolytic drug used in some countries. In order to understand the mechanism of this antioxidant action of Caroverine we studied the interaction of

The quinoxaline derivative caroverine in the treatment of sensorineural smell disorders: a proof-of-concept study.

Christian Quint et al.

Acta oto-laryngologica, 122(8), 877-881 (2003-01-25)

The treatment of non-conductive olfactory disorders is to a large extent an unsolved problem. This proof-of-concept study focused on possible effects of the N-methyl-D-aspartate (NMDA) antagonist caroverine. Potential mechanisms for the hypothesized effect included reduced feedback inhibition in the olfactory

Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat.

Maoli Duan et al.

Acta oto-laryngologica, 126(11), 1140-1147 (2006-10-20)

Physiological and morphological assessments indicated that low-dose and long-term caroverine delivery might be a new approach to protect against impulse noise-induced hearing loss. Although the exact mechanisms by which impulse noise causes hearing loss are still unclear, there is accumulating

Blocking AMPA receptor signalling by caroverine infusion does not affect counter-regulation of hypoglycaemia in healthy men.

J Klement et al.

Diabetologia, 52(6), 1192-1196 (2009-04-04)

Glutamatergic pathways are assumed to play a critical role in the hormonal stress response to hypoglycaemia. In rats, glutamate signalling at the amino-3-hydroxy-5-methyl-4-isoxazol propionate (AMPA) receptor contributes to hormone release induced by behavioural stressors. We hypothesised that blocking the AMPA

Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs.

Zhiqiang Chen et al.

Audiology & neuro-otology, 8(1), 49-56 (2003-02-05)

Caroverine, an N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, has been shown to protect the inner ear from excitotoxicity and to be effective in the treatment of cochlear synaptic tinnitus. Local administration of caroverine on the round window membrane (RWM) could

Alle zugehörigen Dokumente anzeigen

Global Trade Item Number

SKU	GTIN
C1119-10MG	04061832081328
C1119-50MG	04061832081335

Questions

Reviews

No rating value

Active Filters

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung