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B104

Sigma-Aldrich

tert-Butyl-bicyclo[2.2.2]phosphorthionat

solid

Synonym(e):

TBPS

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About This Item

Empirische Formel (Hill-System):
C8H15O3PS
CAS-Nummer:
70636-86-1
Molekulargewicht:
222.24
MDL-Nummer:
MFCD00168049
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24891554
NACRES:
NA.77

Form

solid

Farbe

white to pink

Löslichkeit

DMSO: soluble
H2O: slightly soluble
ethanol: soluble

Lagertemp.

2-8°C

SMILES String

CC(C)(C)[C@@]12COP(=S)(OC1)OC2

InChI

1S/C8H15O3PS/c1-7(2,3)8-4-9-12(13,10-5-8)11-6-8/h4-6H2,1-3H3/t8-,12?

InChIKey

VTBHBNXGFPTBJL-KRDXSZEZSA-N

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Allgemeine Beschreibung

Aqueous solubility may be enhanced by the use of non-ionic detergents (Brij, Tween) or 2-hydroxypropyl-β-cyclodextrin.

Biochem./physiol. Wirkung

GABAA receptor antagonist; chloride channel blocker; extremely potent convulsant.

Leistungsmerkmale und Vorteile

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

Solutions may be stored for 1-2 days at 4 °C.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Daniel A García et al.
European journal of pharmacology, 600(1-3), 26-31 (2008-10-22)
Thymol is a monoterpene that specifically interacts with synaptic neural functions in neuronal GABA-operated Cl(-) channels. Here we explore the effects of thymol, and propofol as positive control, on t-[(35)S]butylbicyclophosphorothionate ([(35)S]TBPS) binding in primary cultures of cortical neurons. The study
Alex S Evers et al.
The Journal of pharmacology and experimental therapeutics, 333(2), 404-413 (2010-02-04)
In the absence of GABA, neuroactive steroids that enhance GABA-mediated currents modulate binding of [35S]t-butylbicyclophosphorothionate in a biphasic manner, with enhancement of binding at low concentrations (site NS1) and inhibition at higher concentrations (site NS2). In the current study, compound
Shirin Strohmeier et al.
Pathogens (Basel, Switzerland), 8(4) (2019-10-24)
H11 subtype influenza viruses were isolated from a wide range of bird species and one strain also was isolated from swine. In an effort to generate reagents for a chimeric H11/1 hemagglutinin-based universal influenza virus vaccine candidate, we produced 28
J C Behrends
British journal of pharmacology, 129(2), 402-408 (2000-02-29)
1. T-butyl-bicyclo-phosphorothionate (TBPS) is a prototypical representative of the cage-convulsants which act through a use-dependent block of the GABA(A)-receptor-ionophore complex. Using current recordings from cultured neurones of rat striatum the manner was investigated in which two antagonists, bicuculline and penicillin
M H Tehrani et al.
Journal of neurochemistry, 46(5), 1542-1548 (1986-05-01)
The role of t-butylbicyclophosphorothionate (TBPS) as an antagonist of gamma-aminobutyric acid (GABA) was studied with primary cultures of neurons from the chick embryo cerebrum. The addition of GABA stimulated the uptake of 36Cl- by neurons and the dose dependence of
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