A7475
Anthopleurin-A -trifluoracetat (Salz)
>88% (HPLC)
Synonym(e):
AP-A trifluoroacetate salt, Anthopleura toxin A trifluoroacetate salt
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Über diesen Artikel
Empirische Formel (Hill-System):
C220H326N64O67S6 · xC2HF3O2
Molekulargewicht:
5131.72 (free base basis)
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
Assay:
>88% (HPLC)
Form:
solid
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Unterstützung erhaltenassay
>88% (HPLC)
form
solid
storage temp.
−20°C
General description
Synthetic peptide toxin that was originally isolated from the sea anemone, Anthopleura xanthogrammica.
Synthetic peptide toxin.
Application
Anthopleurin-A is a toxin used to study the gating mechanisms of sodium channels. Anthopleurin-A slows the repolarization phase of nerve and muscle action potentials by inactivating the sodium channel.
Biochem/physiol Actions
Anthopleurin-A slows the repolarization phase of nerve and muscle action potentials by inactivating the sodium channel.[1] Anthopleurin-A shows a preference towards cardiac channels over the neuronal sodium channels.[2] It is a toxin used to study the gating mechanisms of sodium channels.[1]
Shown to have inotropic effects and not chronotropic effects on mammalian heart preparations.
Other Notes
supplied as trifluoroacetate salt
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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M J Scanlon et al.
Protein science : a publication of the Protein Society, 3(7), 1121-1124 (1994-07-01)
Anthopleurin-A (AP-A) is a member of a family of sea anemone-derived polypeptides that interact with sodium channels in a voltage-dependent manner, producing a positive inotropic effect on the mammalian heart. There has been considerable interest in this molecule as a
Y Pichon
Journal of physiology, Paris, 89(4-6), 171-180 (1995-01-01)
The physiological function of the axon is to conduct short all-or-none action potentials from their site of initiation (usually the cell body) to the synapse. To ensure this function, both passive and active biophysical properties of the axons are tuned
Daisuke Izumi et al.
Heart rhythm, 9(5), 796-803 (2011-11-30)
Previous studies have showed that the interval between the peak and the end of the T wave (Tp-e) is a marker of transmural dispersion of ventricular repolarization. We studied the relationship between (a) the Tp-e on local pseudo transmural electrograms
P K Pallaghy et al.
Biochemistry, 34(11), 3782-3794 (1995-03-21)
The three-dimensional structure in aqueous solution of the 49-residue polypeptide anthopleurin-A (AP-A), from the sea anemone Anthopleura xanthogrammica, has been determined from 1H NMR data. A restraint set consisting of 411 interproton distance restraints inferred from NOEs and 19 backbone
Y Chung et al.
The American journal of physiology, 271(2 Pt 2), H687-H695 (1996-08-01)
Perfused rat heart experiments focused on determining the critical O2 level in postischemic myocardium. After a 20-min global ischemia, reperfusion began with O2-saturated saline buffer reflowing at different rates (0.5-12 ml/min). The 1H nuclear magnetic resonance (NMR) signal of the
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