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A0606

Aurothioglukose

≥96% (titration), PKCι-Par6 interaction inhibitor, powder

Synonym(e):

Aurothioglucose

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5 MG

€ 197,00

25 MG

€ 598,00

€ 197,00

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Über diesen Artikel

Empirische Formel (Hill-System):
C6H11AuO5S · xH2O
CAS-Nummer:
12192-57-3
Molekulargewicht:
392.18 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24724383
NACRES:
NA.77
EC Number:
235-365-7
Assay:
≥96% (titration)
Form:
powder
Storage condition:
desiccated

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Produktname

Aurothioglukose, ≥96% (titration)

assay

≥96% (titration)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1

InChI key

SGVIEHTYEMEDRR-PKXGBZFFSA-M

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Dieser Artikel
O60043541N9412
Aurothioglucose hydrate ≥96% (titration)

A0606

Aurothioglucose hydrate

Octyl β-D-1-thioglucopyranoside ≥98.0% (GC)

Sigma-Aldrich

O6004

Octyl β-D-1-thioglucopyranoside

Glutathione, Reduced, Free Acid Glutathione, Reduced, Free Acid, CAS 70-18-8, is a tripeptide that serves as an endogenous antioxidant and provides protection against auto-oxidation.

Sigma-Aldrich

3541

Glutathione, Reduced, Free Acid

6β-Naltrexol hydrate ≥96% (HPLC), powder

Sigma-Aldrich

N9412

6β-Naltrexol hydrate

assay

≥96% (titration)

assay

≥98.0% (GC)

assay

>98% (titration)

assay

≥96% (HPLC)

form

powder

form

crystalline

form

solid

form

powder

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 5 mg/mL, clear

solubility

-

solubility

water: 1 mg/mL, DMF: 10 mg/mL, ethanol: 5 mg/mL

solubility

DMSO: ~12 mg/mL, H2O: insoluble

storage condition

desiccated

storage condition

-

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

-

Application

Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.[1]

Biochem/physiol Actions

Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.
Potent PKCι-Par6 interaction inhibitor

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000456091
0000456089
0000456091
0000456089
0000381933

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Die Dokumentenbibliothek aufrufen

Kouichi Yoshinari et al.
Pharmaceutical research, 23(6), 1188-1200 (2006-05-23)
Changes in physiological, pathophysiological, and/or nutritional conditions often alter the expression of drug-metabolizing enzymes. In this study, we investigated obesity-induced changes in hepatic cytochrome P450 (P450) levels using nutritionally obese mice. To induce obesity, mice were fed a high-fat diet
Eric N van Roon et al.
The Journal of rheumatology, 32(6), 1026-1030 (2005-06-09)
For reasons of insufficient quality of the raw material, aurothioglucose was withdrawn from the Dutch market at the end of 2001. Aurothiomalate became available as an alternative preparation. We followed a cohort of patients during the first year after switching
Mitsunari Ogasawara et al.
Liver international : official journal of the International Association for the Study of the Liver, 31(4), 542-551 (2011-03-09)
The search for effective treatments of non-alcoholic steatohepatitis (NASH), now the most common chronic liver disease in affluent countries, is hindered by a lack of animal models having the range of anthropometric and pathophysiological features as human NASH. To examine
P Huypens et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 38(8), 486-490 (2006-08-31)
Following the chemically-induced lesion of the ventromedial nucleus, gold-thioglucose treated rodents display hypothalamic leptin resistance, hyperphagia, hyperinsulinemia and obesity. Despite the exuberant hyperinsulinemia following gold-thioglucose treatment, systemic insulin sensitivity is preserved during the early phase of the obesity syndrome, resulting
Fumiko Isoda et al.
Brain research, 993(1-2), 172-176 (2003-12-04)
D-chiro-Inositol (DCI) enhances reproductive function in insulin-resistant women with polycystic ovarian disease and enhances the effects of insulin in the periphery, suggesting that this compound may act in part by sensitizing the hypothalamus to effects of insulin. Effects of gold-thioglucose
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Artikel

Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

Global Trade Item Number

SKUGTIN
A0606-25MG04061832433738
A0606-5MG04061832433745

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