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Merck

76308

Pefabloc® TH

acetate salt, ≥90% (HPLC)

Synonym(e):

4-Amidino-Nα-(naphthalin-2-sulfonylglycyl)-DL-phenylalanin-piperidid -acetat (Salz), NAPAP

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Über diesen Artikel

Empirische Formel (Hill-System):
C27H31N5O4S · C2H4O2
Molekulargewicht:
581.68
UNSPSC Code:
12352202
PubChem Substance ID:
329767027
MDL number:
MFCD01311055

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InChI

1S/C27H31N5O4S.C2H4O2/c28-26(29)21-10-8-19(9-11-21)16-24(27(34)32-14-4-1-5-15-32)31-25(33)18-30-37(35,36)23-13-12-20-6-2-3-7-22(20)17-23;1-2(3)4/h2-3,6-13,17,24,30H,1,4-5,14-16,18H2,(H3,28,29)(H,31,33);1H3,(H,3,4)

SMILES string

CC(O)=O.NC(=N)c1ccc(CC(NC(=O)CNS(=O)(=O)c2ccc3ccccc3c2)C(=O)N4CCCCC4)cc1

InChI key

ZBMVAFLDTKWMBP-UHFFFAOYSA-N

biological source

synthetic

assay

≥90% (HPLC)

form

flakes, powder or crystals

Gene Information

human ... F2(2147), PLAT(5327), PLG(5340), PRSS1(5644)

Application

Thrombin inhibitor; used in 3-D modeling of snake venom serine proteases to elucidate the differences with thrombin in their inhibitory domains.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Legal Information

Pefabloc is a registered trademark of Pentapharm

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Analysenzertifikate (COA)

Lot/Batch Number
BCBQ3757V
BCBM9435V
BCBM7240V
BCBL9280V

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Efrat Shavit-Stein et al.
Frontiers in neurology, 9, 1139-1139 (2019-01-22)
Thrombin and its protease-activated receptor 1 (PAR1) are potentially important in peripheral nerve inflammatory diseases. We studied the role of thrombin and PAR1 in rat experimental autoimmune neuritis (EAN), a model of the human Guillain-Barré syndrome (GBS). EAN was induced
Gilad Reuveni et al.
Neuroreport, 28(17), 1176-1179 (2017-09-16)
Thrombin is a coagulation factor implicated in various pathological and physiological processes in the brain, exerting beneficial and deleterious effects in a concentration-dependent manner. Measurement of thrombin activity levels in pathological animal models is needed and in some cases, because
Efrat Shavit-Stein et al.
PloS one, 14(7), e0219453-e0219453 (2019-07-06)
Diabetic neuropathy is common and disabling despite glycemic control. Novel neuroprotective approaches are needed. Thrombin and hypercoagulability are associated with diabetes and nerve conduction dysfunction. Our aim was to study the role of thrombin in diabetic neuropathy. We measured thrombin
Ekaterina Mindel et al.
Journal of neuroscience research, 99(3), 966-976 (2020-12-10)
Many coagulation factor proteases are increased in the brain during ischemic stroke. One of these proteases is plasmin. In this study we established a novel method for direct quantitative measurement of plasmin activity in male mouse brain slices using a
Valery Golderman et al.
International journal of molecular sciences, 21(7) (2020-04-05)
Neural inflammation is linked to coagulation. Low levels of thrombin have a neuroprotective effect, mediated by activated protein C (APC). We describe a sensitive novel method for the measurement of APC activity at the low concentrations found in neural tissue.
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