350R-2

FOXP1 (EP137) Rabbit Monoclonal Primary Antibody

• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: EP137, monoclonal
• Application: IHC (p)
• Citations: 9

Eigenschaften

• biological source: rabbit
• Quality Level: 100, 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP137, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (350R-24), vial of 0.1 mL concentrate Research Use Only (350R-24-RUO), vial of 0.5 mL concentrate (350R-25), vial of 1.0 mL concentrate (350R-26), vial of 1.0 mL concentrate Research Use Only (350R-26-RUO), vial of 1.0 mL pre-dilute Research Use Only (350R-27-RUO), vial of 1.0 mL pre-dilute ready-to-use (350R-27), vial of 7.0 mL pre-dilute ready-to-use (350R-28), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (350R-28-RUO)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
• isotype: IgG
• control: lymph node, tonsil
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear
• Gene Information: human ... FOXP1(27086)

Beschreibung

General description

Diffuse large B-cell lymphoma (DLBCL) most likely represents different clinicopathologic entities, which are difficult to separate using standard technique.[1] Diffuse large B-cell lymphoma (DLBCL) can be divided into the subtypes of germinal center B-cell–like (GCB), activated B-cell–like (ABC), and unclassified DLBCL.[1][2][3] The GCB and ABC subtypes have different pathogenetic mechanisms that will impact the development of targeted therapies.[2] Despite the robustness of gene expression profiling (GEP) in subclassifying DLBCL, GEP techniques are not applicable to the routine clinical practice due to the substantial time, technological expertise, and scarce resources required. Therefore, it is beneficial for the translational application of the GEP classification into protein expression by tumor cells to be developed through immunohistochemical (IHC) staining of formalin-fixed, paraffin-embedded tissues. Different approaches using immunophenotypic algorithms with small panels of antibody biomarkers have been developed to translate the robust information from molecular studies into a routine clinical platform,[4][5][6][7][8] using antibodies against CD10, BCL6, MUM1/IRF4, GCET1, FoxP1, LMO2, and BCL2. Therefore, FoxP1 is useful in subclassification of DLBCL and a high cutoff (80%) for FoxP1 is needed to achieve high specificity for the ABC subtype.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

IVD

IVD

IVD

RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

FoxP1 Positive Control Slides, Product No. 350S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 2