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Y0000359

Acebutolol Unreinheit B

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

N-{3-Acetyl-4-{(2RS)-2-hydroxy-3-[(1-methylethyl)-amino]-propoxy}-phenyl}-acetamid, Diacetolol

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About This Item

Empirische Formel (Hill-System):
C16H24N2O4
CAS-Nummer:
Molekulargewicht:
308.37
UNSPSC-Code:
41116107
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

acebutolol

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

InChI

1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)

InChIKey

AWOGXJOBNAWQSF-UHFFFAOYSA-N

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Acebutolol impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

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Analysenzertifikate (COA)

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M Piquette-Miller et al.
Agents and actions, 37(3-4), 290-296 (1992-11-01)
Disease states such as arthritis may interact with the kinetics of beta-blockers. Acebutolol (AC) is a chiral beta-blocker which is available as a racemate. The beneficial properties of AC, however, is attributed mainly to the S-(+)-enantiomer. The disposition of AC
D R Abernethy et al.
American heart journal, 109(5 Pt 2), 1120-1125 (1985-05-01)
Studies in various animal models have shown acebutolol to be a relatively cardioselective beta-adrenoceptor-blocking agent possessing both partial agonist and membrane-stabilizing activities. The latter property may not be significant at clinically used doses. Acebutolol has both antihypertensive and antiarrhythmic effects.
M S Thomas et al.
European journal of clinical pharmacology, 29(6), 679-683 (1986-01-01)
The beta-adrenergic selectivity of diacetolol, the major metabolite of acebutolol, has been compared with that of acebutolol, metoprolol and propranolol in 11 normal subjects. Bronchial and cardiac beta-adrenoceptor blockade were assessed on separate occasions after diacetolol 600 mg, acebutolol 400
Jari J Lilja et al.
British journal of clinical pharmacology, 60(6), 659-663 (2005-11-25)
We aimed to investigate effects of grapefruit juice on acebutolol pharmacokinetics. In a randomized cross-over study, 10 healthy subjects ingested 200 mL grapefruit juice or water three times daily for 3 days and twice on day 4. On day 3
N V Fergusson et al.
Annals of the Royal College of Surgeons of England, 67(2), 124-126 (1985-03-01)
Twenty eight patients were randomly allocated into treatment or placebo groups. The treatment group received a single 400 mg oral dose of acebutolol, the placebo group an identical inert prepation. A blood sample from each patient was subsequently analysed for

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