SBR00026

Ligstroside

Nitric oxide inhibitor, ≥95%

• Synonym(e): (-)-ligstroside, Ligustroside
• Empirische Formel (Hill-System): C₂₅H₃₂O₁₂
• CAS-Nummer: 35897-92-8
• Molekulargewicht: 524.51
• UNSPSC-Code: 12352200
• NACRES: NA.25

Eigenschaften

• Biologische Quelle: plant
• Qualitätsniveau: 100
• Assay: ≥95%
• Form: lyophilized powder
• Mol-Gew.: 524.51
• Löslichkeit: DMSO: ≥10 mg/mL (19 mM); methanol: ≥10 mg/mL
• Anwendung(en): metabolomics; vitamins, nutraceuticals, and natural products
• Lagertemp.: −20°C
• InChI: 1S/C25H32O12/c1-3-15-16(10-19(28)34-9-8-13-4-6-14(27)7-5-13)17(23(32)33-2)12-35-24(15)37-25-22(31)21(30)20(29)18(11-26)36-25/h3-7,12,16,18,20-22,24-27,29-31H,8-11H2,1-2H3/b15-3+/t16-,18+,20+,21-,22+,24-,25-/m0/s1
• InChIKey: GMQXOLRKJQWPNB-MVVLSVRYSA-N

Beschreibung

Allgemeine Beschreibung

Ligstroside, also known as ligusroside, is a secoiridoid glycoside, a bioactive natural compound commonly derived from plants like Ligustrum lucidum, Jasminum officinale, and Osmanthus heterophyllus. Existing research suggests that this metabolite functions as an nitric oxide inhibitor and may exhibit diverse biological activities, including anti-neoplastic, antioxidant, antiviral, and anti-inflammatory properties.

Anwendung

Ligstroside is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem./physiol. Wirkung

Ligstroside is a natural product derived from leaves of Olea europaea. Ligstroside displays several potentially beneficial anti-inflammatory properties by exhibiting selective inhibition effect on COX-1 enzyme of arachidonate cascade metabolism. Ligstroside generates a reduction of the PGE₂ (prostaglandin E₂) levels in activated mouse macrophage (IC50 = 48.53 μM) and also reduction of the TXB₂ (thromboxane B₂) levels in human platelets (IC50 = 122.63 μM). Moreover, Ligstroside exhibits inhibition activity of NO production in LPS-activated RAW264.7 macrophages (17.8% at 30 μM and 40.7% at 100 μM) without any cytotoxic effect in these cells.^, Additionally, Ligstroside exhibits in vitro antiviral activity against parainfluenza type 3 virus (IC50 = 15.6 μM).

Leistungsmerkmale und Vorteile

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

Lagerung und Haltbarkeit

Hygroscopic; store in dry place with desiccant

Sonstige Hinweise

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable