PHR1682

Baclofen

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): (±)-Baclofen
• Empirische Formel (Hill-System): C₁₀H₁₂ClNO₂
• CAS-Nummer: 1134-47-0
• Molekulargewicht: 213.66
• NACRES: NA.24
• PubChem Substance ID: 329823553
• UNSPSC Code: 41116107
• EC Number: 214-486-9
• MDL number: MFCD00055143
• eCl@ss: 25140904

Eigenschaften

• Quality Segment: 300
• grade: certified reference material, pharmaceutical secondary standard
• agency: traceable to Ph. Eur. B0200000, traceable to USP 1048200
• API family: baclofen
• CofA: current certificate can be downloaded
• packaging: pkg of 1 g
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• application(s): pharmaceutical; pharmaceutical; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: ClC1=CC=C(C(CN)CC(O)=O)C=C1
• InChI: 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
• InChI key: KPYSYYIEGFHWSV-UHFFFAOYSA-N
• Gene Information: human ... GABBR1(2550), GABBR2(9568)

Beschreibung

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Baclofen is a structural analog of γ-aminobutyric acid (GABA) and an antispastic agent commonly used for the treatment of spasticity as a result of spinal cord or brain injury.

Application

Baclofen may be used as a pharmaceutical secondary reference standard for the determination of the analyte in plasma samples by liquid chromatography tandem mass spectrometry and tablet formulations by UV spectroscopy, respectively.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

GABA_B receptor agonist; skeletal muscle relaxant; antispastic agent.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA6298 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301
• Sicherheitshinweise: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable