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PHR1081

Supelco

Octisalat

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

2-Ethylhexylsalicylat, Octisalat, Octyl-salicylat

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About This Item

Lineare Formel:
(HO)C6H4CO2CH2CH(C2H5)(CH2)3CH3
CAS-Nummer:
Molekulargewicht:
250.33
Beilstein:
2730664
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to USP 1477943

API-Familie

octisalate

Analysenzertifikat (CofA)

current certificate can be downloaded

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Brechungsindex

n20/D 1.502 (lit.)

bp

189-190 °C/21 mmHg (lit.)

Dichte

1.014 g/mL at 25 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

CCCCC(CC)COC(=O)c1ccccc1O

InChI

1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3

InChIKey

FMRHJJZUHUTGKE-UHFFFAOYSA-N

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Allgemeine Beschreibung

Octisalate is a sunscreen agent that acts as a UV filter for UVB (280-315 nm) radiation.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Octisalate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical and sunscreen formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC0298 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Piktogramme

Environment

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Aquatic Chronic 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

323.6 °F - closed cup

Flammpunkt (°C)

162 °C - closed cup


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Analysenzertifikate (COA)

Lot/Batch Number

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Himmelsbach M, et al.
Analytical and Bioanalytical Chemistry, 406(15), 3647-3656 (2014)
Octisalate
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 43(3), 3194-3194 (2018)
Development and Validation of RP-HPLC Method for Analysis of Four UV Filters in Sunscreen Products
Yousef AN, et al.
International Journal of Pharmaceutical Sciences Review and Research (2013)
M McVean et al.
Molecular carcinogenesis, 24(3), 169-176 (1999-04-16)
Topical application of alpha-tocopherol (alphaTH), the most prominent naturally occurring form of vitamin E, inhibits ultraviolet (UV) B-induced photocarcinogenesis and DNA photodamage in C3H mice in vivo. In this study, we compared alphaTH with other vitamin E compounds and with
Beatriz Albero et al.
Journal of chromatography. A, 1248, 9-17 (2012-06-12)
The determination of organic contaminants in soil is a real challenge due to the large number of these compounds with quite different physico-chemical properties. In the present work, an analytical method was developed for the simultaneous determination in soil of

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