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F0041000

Fenbufen

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

γ-Oxo-(1,1′-biphenyl)-4-buttersäure

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About This Item

Lineare Formel:
C6H5C6H4CO(CH2)2CO2H
CAS-Nummer:
36330-85-5
Molekulargewicht:
254.28
MDL-Nummer:
MFCD00056701
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329799623
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

fenbufen

Hersteller/Markenname

EDQM

mp (Schmelzpunkt)

184-187 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

OC(=O)CCC(=O)c1ccc(cc1)-c2ccccc2

InChI

1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)

InChIKey

ZPAKPRAICRBAOD-UHFFFAOYSA-N

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Fenbufen EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Verpackung

Dieses Produkt wird, wie von der entsprechenden Pharmakopöe geliefert, angeboten. Die aktuellen Mengeneinheiten finden Sie im Referenzsubstanzen-Katalog der EDQM.

Sonstige Hinweise

Sales restrictions may apply.

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Beschreibung
Preisangaben

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

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Die Dokumentenbibliothek aufrufen

A E Sloboda et al.
Arzneimittel-Forschung, 30(4A), 716-721 (1980-01-01)
gamma-Oxo(1,1'-biphenyl)-4-butanoic acid (fenbufen) was shown to be an orally and parenterally effective nonsteroidal antiinflammatory, analgesic and antipyretic agent in a variety of animal species. Like other clinically active antiinflammatory drugs such as acetylsalicylic acid (ASA), indometacin and phenylbutazone, fenbufen has
R N Brogden et al.
Drugs, 21(1), 1-22 (1981-01-01)
Fenbufen is a phenylalkanoic acid derivative with analgesic and anti-inflammatory activity. The anti-inflammatory activity appears to reside in the metabolites. Published data indicate that fenbufen 600 to 1000mg daily is comparable in effectiveness to therapeutic doses (3 to 4g) of
R Andrew Moore et al.
The Cochrane database of systematic reviews, (4)(4), CD007547-CD007547 (2009-10-13)
Fenbufen is a non-selective non-steroidal anti-inflammatory drug (NSAID), used to treat acute and chronic painful conditions. There is no known systematic review of its use in acute postoperative pain. To assess efficacy, duration of action, and associated adverse events of
C Kohler et al.
Arzneimittel-Forschung, 30(4A), 702-707 (1980-01-01)
gamma-Oxo(1,1'-biphenyl)-4-butanoic acid (fenbufen) and biphenylacetic acid have effects on platelets similar to other non-steroidal antiinflammatory agents. In vitro biphenylacetic acid (BPAA), a metabolite of fenbufen, is more potent than fenbufen and in vivo metabolism of fenbufen to BPAA is probably
S S Kerwar
The American journal of medicine, 75(4B), 62-69 (1983-10-31)
Fenbufen (Cinopal) is an orally active nonsteroidal anti-inflammatory drug with analgesic and antipyretic activity. Like clinically used nonsteroidal anti-inflammatory drugs, it shows activity in a wide spectrum of laboratory tests in mice, rats, guinea pigs, and dogs. Fenbufen has a

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