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ATG005
A549 EGFRvIII Antigen Panel Cell Lines
Synonym(e):
A549 Cell Line
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
1 kit | Warenkorb auf Verfügbarkeit prüfen | € 12.790,00 |
Über diesen Artikel
NACRES:
NA.41
UNSPSC Code:
41106514
Biological source:
human lung (carcinoma)
Growth mode:
adherent
Morphology:
epithelial
Technischer Dienst
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Unterstützung erhaltenbiological source
human lung (carcinoma)
growth mode
adherent
morphology
epithelial
shipped in
dry ice
storage temp.
−196°C
General description
This product is a panel of two (2) genetically modified cell lines involving the EGFR gene and the tumor-sepcific EGFRvIII extracellular mutation. The panel consists of a EGFR knockout cell line (EGFR-/-) and an EGFRvIIIhigh expression cell line. The EGFR-/- cell line was generated using CompoZr® Zinc Finger Nuclease technology, and the EGFRvIIIhigh expression cell line was generated using MISSION® lentivirus. The EGFRvIIIhigh cell line expresses EGFRvIII at high levels relative to the EGFR-/- cell line and wild type A549 cells as measured via fluorescence-activated cell sorting (FACS).
The STR profile of these cell lines match that of its parental cell line - ECACC catalog number 86012804.
The STR profile of these cell lines match that of its parental cell line - ECACC catalog number 86012804.
Biochem/physiol Actions
Derived from a 58 year old Caucasian male. The cells can synthesise lecithin utilising the cytidine diphosphocholine pathway. Occasional cells may also contain inclusion bodies although they are not known to carry any human pathogen.
Features and Benefits
The A549 EGFRvIII antigen panel cell lines feature the EGFRvIII extracellular mutation expressed at varying levels (KO and high). These cell lines enable researchers to screen and evaluate the efficacy and potency of EGFRvIII-targeted immunotherapies in a biologically-relevant cellular research model.
Analysis Note
Tested for Mycoplasma, bacterial and fungal content, post-freeze viability, and short terminal repeat (STR) analysis for cell line identification.
Other Notes
ATG005A-1VL: A549 EGFRvIII Knockout
ATG005B-1VL: A549 EGFRvIII High
ATG005B-1VL: A549 EGFRvIII High
Legal Information
CompoZr is a registered trademark of Merck KGaA, Darmstadt, Germany
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
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Dieser Artikel | |||
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| description - | description - | description - | description NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA, 86012804, human lung (carcinoma), Epithelial |
| morphology epithelial | morphology epithelial | morphology Epithelial | morphology Epithelial |
| biological source human lung (carcinoma) | biological source human lung (carcinoma) | biological source human lung (Carcinoma) | biological source human lung (carcinoma) |
| growth mode adherent | growth mode adherent | growth mode Adherent | growth mode Adherent |
| storage temp. −196°C | storage temp. −196°C | storage temp. −196°C | storage temp. −196°C |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
Lagerklasse
10 - Combustible liquids
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