SCT093

BioTracker Mito-Chloride Live Cell Dye

• NACRES: NA.47
• UNSPSC Code: 12352207

Eigenschaften

• form: lyophilized
• mol wt: calculated mol wt 498.41
• packaging: pkg of 1 mg
• manufacturer/tradename: Millipore
• storage condition: protect from light
• growth mode: N/A
• shipped in: ambient
• storage temp.: −20°C

Beschreibung

General description

Mitochondrial membranes contain several ion channels. Among them, mitochondrial chloride channels are involved in the regulation of the mitochondrial volume, maintenance of the mitochondria membrane potential, and apoptosis. The chloride transport activity of these channels is known to be dependent on the mitochondrial pH, with their activity increasing under acidic conditions and decreasing at pH greater than 7.0 (1). BioTracker Mito-Chloride Live Cell Dye is a mitochondrial Cl- selective fluorescent probe. Fluorescence of probe is insensitive to pH over the physiological pH range and is quenched by Cl- with Stern−Volmer quenching constant of 201 M−1 at pH 7.0 (1). This probe can be used to monitor the effects of substances on chloride levels in mitochondria.Reference:1. Park, Sang-Hyun, et al. "Mitochondrial Cl–-Selective Fluorescent Probe for Biological Applications." Analytical Chemistry 92.18 (2020): 12116-12119.

Application

Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.

Features and Benefits

Fluorescent probe for monitoring Cl- in mitochondria.

Physical form

Lyophilized. Yellow solid.

Preparation Note

Store at -20°C, desiccate and protect from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable