MABS383

Anti-NFKBIB Antibody, clone 7B4

ascites fluid, clone 7B4, from mouse

• Synonym(e): IKBB, TRIP9, NFKBIB, NF-kappa-B inhibitor beta, NF-kappa-B, I-kappa-B-beta, IkB-B, IkB-beta, IkappaBbeta, Thyroid receptor-interacting protein 9, R-interacting protein 9, TRIP-9, NFKBIB
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: ascites fluid
• Antikörper-Produkttyp: primary antibodies
• Klon: 7B4, monoclonal
• Speziesreaktivität: human
• Methode(n): western blot: suitable
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: Q15653
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... NFKBIB(4793)

Beschreibung

Allgemeine Beschreibung

NF-kappa-B inhibitor beta inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.Tissue specificity: Expressed in all tissues examined.
The transcription factor NFkappaB (Nuclear Factor kappa B) is involved in the expression and regulation of a number of important cellular and physiological processes such as growth, development, apoptosis, immune and inflammatory response, and activation of various viral promoters including human immunodeficiency virus long terminal repeats. NFkappaB represents a group of structurally related and evolutionarily conserved proteins related to the proto-oncogene c-Rel with five members in mammals that include Rel (cRel), RelA (p65), RelB, NFkappaB1 (p50 and its precursor p105), and NFkappaB2 (p52 and its precursor p100). NFkappaB/Rel proteins exist as homo- or heterodimers to form transcriptionally competent or repressive complexes. Although most NFkappaB dimers are activators of transcription, the p50/50 and p52/52 homodimers can repress the transcription of their target genes. The p50/p65 heterodimer of NFkappaB is the most abundant in cells.

Immunogen

Purified recombinant fragment of human NFKBIB expressed in E. Coli.

Anwendung

Research Category
Zelluläre Signaltransduktion

Research Sub Category
Immunologische Signalübertragung

Detect NFκB using this mouse monoclonal antibody, Anti-NFKBIB Antibody & clone 7B4 validated for use in western blotting.

Qualität

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected NFKBIB in Jurkat cell lysate.

Optimal working dilutions must be determined by end user.

Zielbeschreibung

~50 kDa observed

Physikalische Form

Unpurified

Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Hinweis zur Analyse

Control
Jurkat cell lysate

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable