MABD50

Anti-MyT1L Antibody, clone 20B4.1

clone 20B4.1, from mouse

• Synonym(e): Myelin transcription factor 1-like protein, MyT1-L, MyT1L
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 20B4.1, monoclonal
• Speziesreaktivität: human, mouse
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_055840
• UniProt-Hinterlegungsnummer: Q9UL68
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... MYT1L(23040)

Beschreibung

Allgemeine Beschreibung

Myelin transcription factor 1-like (Myt1L) is a zinc finger protein belonging to the myelin transcription factor 1 family. It influences the expression of genes involved in the proliferation and differentiation of oligodentrocytes in the developing central nervous system. Myt1L may contribute to the silencing of its target genes by recruiting Sin3B that binds to and enhances the activity of HDAC. Several studies have implicated Myt1L in the pathogenesis of complex psychiatric diseases such as schizophrenia, major depressive disorder, and bipolar disorder.

Immunogen

GST-tagged recombinant protein corresponding to human MyT1L.

Anwendung

Research Category
Neurowissenschaft

Research Sub Category
Entwicklungsneurowissenschaft

Detect the MyT1L protein using this Anti-MyT1L, clone 20B4.1 validated for use in WB & IHC.

Immunohistochemistry Analysis: A 1:10-1:50 dilution from a representative lot detected MyT1L in human pons, mouse frontal cortex, and mouse hippocampus tissues.

Qualität

Evaluated by Western Blot in mouse E17 spinal cord tissue lysate.

Western Blot Analysis: A 1:1.000 dilution of this antibody detected MyT1L on 10 µg of mouse E17 spinal cord tissue lysate.

Zielbeschreibung

~170 kDa observed. Uniprot describes three isoforms at 21, 126, and 133 kDa

Physikalische Form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
Mouse E17 spinal cord tissue lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable