MAB5416
Anti-Glutamatrezeptor-3-Antikörper, Klon 3B3
clone 3B3, Chemicon®, from mouse
Synonym(e):
AMPA-selective glutamate receptor 3, Glutamate receptor ionotropic, AMPA 3, glutamate receptor 3, glutamate receptor C, glutamate receptor subunit 3, glutamate receptor, ionotrophic, AMPA 3
Über diesen Artikel
Fortfahren mit
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
3B3, monoclonal
species reactivity
monkey, mouse, human
species reactivity (predicted by homology)
rat
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GRIA3(2892)
1 of 4
Dieser Artikel | |||
|---|---|---|---|
| clone 3B3, monoclonal | clone polyclonal | clone polyclonal | clone polyclonal |
| antibody form purified antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| biological source mouse | biological source rabbit | biological source rabbit | biological source rabbit |
| species reactivity monkey, mouse, human | species reactivity rat, human | species reactivity human, rat | species reactivity human, mouse, rat |
| Gene Information human ... GRIA3(2892) | Gene Information human ... GRIA1(2890) | Gene Information human ... GRIA1(2890) | Gene Information human ... GRIA1(2890) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
General description
Immunogen
Application
Optimale Arbeitsverdünnungen müssen vom Endanwender bestimmt werden.
Biochem/physiol Actions
Physical form
Analysis Note
Gehirn
Hippocampus-Gewebe
Legal Information
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Lagerklasse
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysenzertifikate (COA)
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Verwandter Inhalt
Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.
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