8.52419

Fmoc-Cys(THP)-OH

Novabiochem^®

• Synonym(e): Fmoc-Cys(THP)-OH, N-α-Fmoc-S-(tetrahydropyranyl)-L-cysteine
• Empirische Formel (Hill-System): C₂₃H₂₅NO₅S
• CAS-Nummer: 1673576-83-4
• Molekulargewicht: 427.51
• UNSPSC Code: 12352209

Eigenschaften

• Quality Segment: 200
• product line: Novabiochem^®
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: thiol
• storage temp.: 15-25°C

Beschreibung

General description

Fmoc-Cys(Thp)-OH is a new building block for Fmoc SPPS, in which the sulfhydryl group is protected with the acid-cleavable tetrahydropyranyl (Thp) group ^[1]. The use of Fmoc-Cys(Thp)-OH has been shown to give superior results to the corresponding S-Trt, S-Dpm, S-Acm, and S-StBu derivatives.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides

Analysis Note

Colour (visual): white to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (HPLC): ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable