8.52240

Fmoc-D-Tic-OH

Novabiochem^®

• Synonym(e): Fmoc-D-Tic-OH, N-1-Fmoc-D-1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid
• Empirische Formel (Hill-System): C₂₅H₂₁NO₄
• CAS-Nummer: 130309-33-0
• Molekulargewicht: 399.44
• UNSPSC Code: 12352209
• NACRES: NA.22
• MDL number: MFCD00144345

Eigenschaften

• Quality Segment: 200
• product line: Novabiochem^®
• assay: ≥97.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: Fmoc
• storage temp.: 15-25°C
• SMILES string: N4([C@H](Cc5c(cccc5)C4)C(=O)[O-])C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C25H21NO4/c27-24(28)23-13-16-7-1-2-8-17(16)14-26(23)25(29)30-15-22-20-11-5-3-9-18(20)19-10-4-6-12-21(19)22/h1-12,22-23H,13-15H2,(H,27,28)/p-1/t23-/m1/s1
• InChI key: LIRBCUNCXDZOOU-HSZRJFAPSA-M

Beschreibung

General description

Standard building block of introduction of D-Tic amino-acid residues by Fmoc SPPS

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] M. Vincent, et al. (1982) Tetrahedron Lett., 16, 1677.
^[2] P. L. Julian, et al. (1984) J. Am. Chem. Soc., 79, 180.
^[3] W. A. Kazmierski, et al. (1988) Tetrahedron Lett., 44, 697.

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011C)): ≥ 98 %
Purity (TLC(CMA2)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.0 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-13-1065

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable