If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
8.51086
Oxyma Pure
≥99.0% (HPLC), for peptide synthesis, Novabiochem®
Synonym(e):
Oxyma Pure, Ethyl cyano(hydroxyimino)acetate
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Über diesen Artikel
Produktname
Oxyma Pure, Novabiochem®
Quality Segment
product line
Novabiochem®
assay
≥99.0% (HPLC)
form
crystalline powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
mp
130-132 °C
application(s)
peptide synthesis
storage temp.
2-8°C
InChI
1S/C5H6N2O3/c1-2-10-5(8)4(3-6)7-9/h9H,2H2,1H3/b7-4+
InChI key
LCFXLZAXGXOXAP-QPJJXVBHSA-N
General description
Die Bildung von toxischem Cyanwasserstoff (HCN) aus der Reaktion zwischen Oxyma Pure und DIC wurde beobachtet. Glücklicherweise kann diese Nebenreaktion ausgeschlossen werden, indem DIC durch das stärker gehinderte t-Butylcarbodiimid ersetzt wird.
Auswahl von Kopplungsreagenzien
Literatur:
[1] R. Subirós-Funosas, et al. (2009) Chem. Eur. J., 15, 9394
[2] J. Collins , et al. (2014) Org . Lett ., 16, 940.
[3] A. D. McFarland (2019) Org. Process Res. Dev., 23, 2099.
[4] S. R. Manne, et al (2022) Org. Process Res. Dev., 26, 2894.
Application
- Einsatz bei der Synthese schwieriger Peptide.
- Als saurer Modifikator zur Verhinderung von Aspartimid-Bildung.
Features and Benefits
- Kann anstelle von HOBt in mit Carbodiimid vermittelten Kopplungsreaktionen ohne Änderung des Protokolls verwendet werden.
- Führt bei stufenweiser Festphasensynthese zu ähnlichen Ergebnissen wie HOAt.
- Führt in Fragment-Kondensationsreaktionen zu geringerer Epimerisierung als HOBt.
Analysis Note
Aussehen der Substanz (visuell): kristallines Pulver
Gehalt (HPLC, Fl.%): ≥ 99,0 % (a/a)
Identität (IR): entspricht
Löslichkeit (12,5 mmol in 25 ml DMF): klar löslich
Legal Information
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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