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572201

Streptozotocin, CAS-Nr. 18883-66-4, Calbiochem

An N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.

Synonym(e):

Streptozotocin, CAS-Nr. 18883-66-4, Calbiochem

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Über diesen Artikel

Empirische Formel (Hill-System):
C8H15N3O7
CAS-Nummer:
Molekulargewicht:
265.22
UNSPSC Code:
12352103
MDL number:
Assay:
≥95% (HPLC)
Form:
crystalline solid
Storage condition:
OK to freeze


Quality Segment

assay

≥95% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white to pale yellow

solubility

water: soluble

cation traces

heavy metals: ≤5 ppm

shipped in

ambient

storage temp.

−20°C

SMILES string

N(N=O)(C)C(=O)N[C@H]1[C@H](O[C@@H]([C@H]([C@@H]1O)O)CO)O

InChI

1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

InChI key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

General description

Eine N-Nitroso-haltige Verbindung, die in den Inselzellen der Bauchspeicheldrüse als Stickstoffoxid-Donator wirkt. Ein Antibiotikum, das gegen gramnegative Bakterien wirkt. Verursacht DNA-Alkylierung und DNA-Strangbrüche in Inselzellen der Bauchspeicheldrüse. Ein diabetogenen Mittel.
Eine N-Nitroso-haltige diabetogene Verbindung, die in den Inselzellen der Bauchspeicheldrüse als Stickstoffoxid-Donator wirkt. Ein Antibiotikum, das gegen gramnegative Bakterien wirkt. Verursacht DNA-Alkylierung und DNA-Strangbrüche in Inselzellen der Bauchspeicheldrüse.

Preparation Note

In Lösung instabil; unmittelbar vor der Verwendung rekonstituieren. Nach dem erstmaligen Auftauen in Aliquote aufteilen und einfrieren (-20 °C).

Other Notes

Kroncke, K.D., et al. 1995. Biol. Chem. Hoppe Seyler376, 179.
Kwon, N.S., et al. 1994. FASEB J.8, 529.
Rasschaert, J., et al. 1992. Endokrinologie130, 3522.
Bennett, R.A. und Pegg, A.E. 1981. Cancer Res.41, 2786.
Yamamoto, H., et al. 1981. Nature294, 284.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxizität: Gesundheitsschädlich & Karzinogen / Teratogen (E)


pictograms

FlameHealth hazard

signalword

Danger

Hazard Classifications

Carc. 2 - Flam. Sol. 1 - Muta. 2

Lagerklasse

4.1B - Flammable solid hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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