5.05313

Hexamethonium Bromide

• Synonym(e): Hexamethonium Bromide, Hexane-1,6-bis(trimethylammonium bromide), Nicotinic Acetylcholine Receptors (nAChRs) Antagonist, Hexamethonium Bromide
• Empirische Formel (Hill-System): C₁₂H₃₀Br₂N₂
• CAS-Nummer: 55-97-0
• Molekulargewicht: 362.19
• MDL-Nummer: MFCD00011787
• UNSPSC-Code: 12352200

Eigenschaften

• Assay: ≥98% (TLC)
• Qualitätsniveau: 100
• Form: powder
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white
• Löslichkeit: H₂O: 100 mg/mL
• Lagertemp.: 10-30°C
• InChI: 1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
• InChIKey: FAPSXSAPXXJTOU-UHFFFAOYSA-L

Beschreibung

Allgemeine Beschreibung

A potent antagonist of nicotinic acetylcholine receptors (nAChRs) at pre-ganglionic sites in both the sympathetic and parasympathetic nervous systems. Often used for studying the roles of nicotinic receptors in regulating cardiovascular system.

Biochem./physiol. Wirkung

Primary Target
nAChR

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Dasgupta, X., et al., 2010. Proc. Natl. Acad. Sci.103, 6332.
Karavaev, N., et al., 2008. Neurosci. Behav. Physiol.38, 297.
Nelson, E., 1999. J. Physiol.516, 657.
Christ, D. 1980. Br. J. Pharmacol.69, 249.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable