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H0879

Sigma-Aldrich

Hexamethoniumbromid

Synonym(e):

N,N,N,N′,N′,N′-Hexamethyl-hexamethylendiammonium-dibromid

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About This Item

Lineare Formel:
(CH3)3N(Br)(CH2)6N(Br)(CH3)3
CAS-Nummer:
55-97-0
Molekulargewicht:
362.19
Beilstein:
3715749
EG-Nummer:
200-249-7
MDL-Nummer:
MFCD00011787
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278459
NACRES:
NA.77

mp (Schmelzpunkt)

282-285 °C (dec.)

SMILES String

[Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C

InChI

1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2

InChIKey

FAPSXSAPXXJTOU-UHFFFAOYSA-L

Angaben zum Gen

human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143)

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Anwendung

Hexamethonium bromide has been used:
  • as an autonomic ganglia-blocking agent to study its effects on whisker movement in rats
  • as a nicotinic receptor antagonist to study its effects on antigen-induced arthritis (AIA) progression in mice
  • as a non-selective ganglionic nicotinic acetylcholine receptor (nAChR) antagonist to study its effects on cytisine-induced autonomic cardiovascular responses in mice

Biochem./physiol. Wirkung

Hexamethonium bromide is a nicotinic acetylcholine receptor (nAChR) antagonist. It preferentially blocks nicotinic receptors at autonomic ganglia. It can cross the blood-brain barrier only at high doses.

Leistungsmerkmale und Vorteile

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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