5.05227

(-)-Cytisine

• Synonym(e): (-)-Cytisine, nAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine
• Empirische Formel (Hill-System): C₁₁H₁₄N₂O
• CAS-Nummer: 485-35-8
• Molekulargewicht: 190.24
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00136048
• Assay: ≥99% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• assay: ≥99% (HPLC)
• Quality Segment: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: pale yellow
• solubility: water: 100 mM
• storage temp.: 2-8°C
• SMILES string: N21C[C@@H]3CNC[C@H](C3)C2=CC=CC1=O
• InChI: 1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9-/m0/s1
• InChI key: ANJTVLIZGCUXLD-IUCAKERBSA-N

Beschreibung

General description

A potent agonist selective for neuronal nAChRs (K_i = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.

Biochem/physiol Actions

Primary Target
nAChR

Reversible: yes

Target K_i: 2, 5890, 480, 329, and 492 nM at &alpha

Preparation Note

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chen, Y., et al., 2012. Br J Pharmacol.165, 1006.
West, R., 2011, N. Engl. J. Med.365, 1193.

Happe, K., et al., 1994. Neurosci.62, 929.

Reavill, C. et al., 1990. Neuropharmacol.29, 619.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301 + H311 + H331
• Sicherheitshinweise: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects