481990

Nigericin, Sodium Salt, Streptomyces hygroscopicus

Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

• Synonym(e): Nigericin, Sodium Salt, Streptomyces hygroscopicus, Antibiotic K178
• Empirische Formel (Hill-System): C₄₀H₆₇O₁₁ · Na
• CAS-Nummer: 28643-80-3
• Molekulargewicht: 746.94
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD00036825
• Assay: ≥98% (TLC)
• Form: lyophilized
• Quality level: 100
• Storage condition: OK to freeze

Eigenschaften

• Quality Level: 100
• assay: ≥98% (TLC)
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• solubility: chloroform: soluble, ethanol: soluble, ethyl acetate: soluble
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
• InChI key: MOYOTUKECQMGHE-KKCUGXASSA-M

Beschreibung

General description

A monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H⁺ (antiport). Transports monovalent cations across membranes with the following specificities: K⁺>Rb⁺>Cs⁺>>Na⁺. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.

Disrupts the membrane potential and stimulates ATPase activity in mitochondria. Transports monovalent cations across membranes with the following specificity: K⁺>Rb⁺>Cs⁺>>Na⁺.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Moriyama, Y., et al. 1994. J. Biochem.115, 213.
Eytan, G.D., et al. 1990. J. Biol. Chem.265, 12949.
Alonso, M.A., and Carrasco, L. 1981. FEBS Lett.127, 112.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H319
• pcodes: P264 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3