481920-M

NAAG

NAAG is a neuropeptide and a neurotransmitter that is abundant in the mammalian nervous system.

• Synonym(e): NAAG, N-Acetyl-Asp-Glu, N-acetylaspartylglutamate;Spaglumic acid
• Empirische Formel (Hill-System): C₁₁H₁₆N₂O₈
• CAS-Nummer: 3106-85-2
• Molekulargewicht: 304.25
• UNSPSC Code: 12352200
• MDL number: MFCD00076652
• NACRES: NA.77
• Assay: ≥98% (TLC)
• Form: powder
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (TLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 50 mg/mL, methanol: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: [Mg+2].N([C@@H](CCC(=O)[O-])C(=O)[O-])C(=O)[C@@H](NC(=O)C)CC(=O)[O-].[H+]
• InChI: 1S/C11H16N2O8.Mg/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16;/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21);/q;+2/p-2/t6-,7-;/m0./s1
• InChI key: BQAXDBLSAIPBND-LEUCUCNGSA-L

Beschreibung

General description

NAAG is a neuropeptide and a neurotransmitter that is abundant in the mammalian nervous system. It remains uncertain whether this compound activates NMDA receptors; however, it is clearly demonstrated to act as a selective agonist of mGluR3, both in vitro and in vivo.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Neale, J., et al. 2011. J. Neurochem.12, in press; Neal, J., et al. 2011. J. Neurochem.118, 490; Adedoyin, M., et al. 2010. Mol. Pain6, 60; Chopra M., et al. 2009. J. Pharmacol. Exp. Ther.330, 212; Fricker, A., et al. 2009. Neuropharmacology56, 1060; Neale, J.,et al. 2005. Trends Pharmacol. Sci.29, 477; Westbrook, G., et al. 1986. J. Neurosci.11, 3385; Koller, K., et al. 1984. J. Neurochem.43, 1136; Curatolo, A., et al. 1965, J. Neurochem.12, 339.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable