370625

Guanabenz Acetate

A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostatis regulator.

• Synonym(e): Guanabenz Acetate, 1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678
• Empirische Formel (Hill-System): C₈H₈Cl₂N₄ · xC₂H₄O₂
• CAS-Nummer: 23256-50-0
• Molekulargewicht: 231.08 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00153801
• Assay: ≥99% (HPLC)
• Form: powder
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥99% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: white
• solubility: water: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Clc1c(c(ccc1)Cl)\C=N\N=C(\[N+H3])/N.[O-]C(=O)C
• InChI: 1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;
• InChI key: MCSPBPXATWBACD-GAYQJXMFSA-N

Beschreibung

General description

A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC₅₀ ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Tsaytler, P., et al. 2011. Science332, 91.
Erb, S., et al. 2000. Neuropsychopharmacology23, 138,
Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol.327, 1.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable