361548

GSK-3β Inhibitor VII

The GSK-3β Inhibitor VII, also referenced under CAS 99-73-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(e): GSK-3β Inhibitor VII, α-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor
• Empirische Formel (Hill-System): C₈H₆Br₂O
• CAS-Nummer: 99-73-0
• Molekulargewicht: 277.94
• UNSPSC Code: 12352100
• NACRES: NA.77
• MDL number: MFCD00000200
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated, protect from light

Eigenschaften

• description: RTECS - AM6950000
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated, protect from light
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: BrCC(=O)c1ccc(cc1)Br
• InChI: 1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
• InChI key: FKJSFKCZZIXQIP-UHFFFAOYSA-N

Beschreibung

General description

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 0.5 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 0.5 µM against GSK-3β

Packaging

Packaged under inert gas

Other Notes

Conde, S., et al. 2003. J. Med. Chem.46, 4631.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Danger
• Gefahrencodes: H314
• Sicherheitshinweise: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Skin Corr. 1B
• Lagerklasse: 8A - Combustible corrosive hazardous materials
• Was ist los?: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable