341273

Factor D, Human

Factor D, Human, is a native single-chain glycoprotein with serine protease activity. Cleaves, and thus activates, Factor B during activation of complement via the alternative pathway.

• Synonym(e): C3 Activator Convertase, Adipsin
• NACRES: NA.25
• UNSPSC Code: 12352202
• Form: liquid
• Assay: ≥90% (SDS-PAGE)

Eigenschaften

• Quality Segment: 100
• assay: ≥90% (SDS-PAGE)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, avoid repeated freeze/thaw cycles
• shipped in: wet ice
• storage temp.: −70°C

Beschreibung

General description

Native factor D from human serum. Single-chain glycoprotein composed of 222 amino acids, present in normal human serum at about 1.4 µg/ml. Serine protease that cleaves, and thus activates, Factor B during activation of complement via the alternative pathway. Has recently been shown to be identical to adipsin, a serine protease secreted into the bloodstream by adipocytes.

Biochem/physiol Actions

IgG, IgA, IgM, Factor H, Factor B, or albumin: ≤trace amounts

Physical form

In PBS, pH 7.2.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Jing, H., et al. 1999. EMBO J.18, 804.
Volankis, J.E., et al. 1985. N. Engl. J. Med. 312, 395.
Niemann, M.A., et al. 1984. J. Immunol. 132, 809.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Was ist los?: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable