219674

CFTR Inhibitor-172

InSolution, ≥95%

• Synonym(e): InSolution CFTR Inhibitor-172, (Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTR_inh-172 in DMSO, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone, (Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTR_inh-172 in DMSO
• Empirische Formel (Hill-System): C₁₈H₁₀F₃NO₃S₂
• CAS-Nummer: 307510-92-5
• Molekulargewicht: 409.40
• MDL-Nummer: MFCD06411408
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: liquid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• InChI: 1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8-
• InChIKey: JIMHYXZZCWVCMI-ZSOIEALJSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl^- transport in human airway cells (K_i ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl^- channels, MDR-1, ATP-sensitive K⁺ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. The solid form of this compound (Cat. No. 219670) is also available.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
CFTR ion-channel

Reversible: yes

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Irritant (B)

Physikalische Form

A 50 mM (5 mg/244 µL) solution of CFTR Inhibitor-172 (Cat. No. 219670) in DMSO.

Rekonstituierung

Following initial thaw, aliquot and freeze (70°C). Aliquots are stable for up to 3 months at -70°C.

Sonstige Hinweise

Yang, H., et al. 2003. J. Biol. Chem.278, 35079.
Al-Awqati, Q., et al. 2002. J. Clin. Invest.110, 1599.
Ma, T., et al. 2002. J. Clin. Invest.110, 1651.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): 188.6 °F - closed cup - (refers to pure substance)
• Flammpunkt (°C): 87 °C - closed cup - (refers to pure substance)