110165CBC

Thiamet G

TMG

• Synonym(e): O-GlcNAcase Inhibitor, (3aR,5R,6S,7R,7aR)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-Pyrano[3,2-d]thiazole-6,7-diol
• Empirische Formel (Hill-System): C₉H₁₆N₂O₄S
• CAS-Nummer: 1009816-48-1
• Molekulargewicht: 248.30
• UNSPSC Code: 12352200
• NACRES: NA.28
• MDL number: MFCD15144964

Eigenschaften

• Quality Segment: 100
• SMILES string: CCNC1=N[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]2S1
• InChI: 1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1
• InChI key: PPAIMZHKIXDJRN-FMDGEEDCSA-N

Beschreibung

Biochem/physiol Actions

Thiamet G is a glycosidase inhibitor

Thiamet G is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet G leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and hippocampus.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1B
• Lagerklasse: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable