860819P

20:0(2R-OH) Ceramide

Avanti Research^™ - A Croda Brand 860819P, powder

• Synonym(e): N-(2′-(R)-hydroxyarachidoyl)-D-erythro-sphingosine
• Empirische Formel (Hill-System): C₃₈H₇₅NO₄
• CAS-Nummer: 943147-54-4
• Molekulargewicht: 610.01
• MDL-Nummer: MFCD22416675
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 5 mg (860819P-5mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 860819P
• Lipid-Typ: sphingolipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCCCCCC)=O)CO
• InChI: 1S/C38H75NO4/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-33-37(42)38(43)39-35(34-40)36(41)32-30-28-26-24-22-20-16-14-12-10-8-6-4-2/h30,32,35-37,40-42H,3-29,31,33-34H2,1-2H3,(H,39,43)/b32-30+/t35-,36+,37+/m0/s1
• InChIKey: CFYLSUZUMMPFNC-PLHXSOCRSA-N

Beschreibung

Allgemeine Beschreibung

Ceramides containing 2-hydroxy fatty acids (hFA) group are mainly found in the epidermis.[1] 20:0(2R-OH) Ceramide is a 2R hydroxylated arachidic acid-containing ceramide.[2]

Biochem./physiol. Wirkung

Hydroxy fatty acid (hFA)-sphingolipids play a vital role in cell signaling. hFA-ceramides contribute to the permeability barrier function of the surface epithelium of the skin. Fatty acid 2-hydroxylase (FA2H) catalyzes the synthesis of hFA-ceramides. Impaired function of FA2H causes nervous system disorders leukodystrophy and spastic paraparesis in humans.[3] hFA-ceramides are essential for PM02734, an antitumor drug to exhibit its activity.[4]

Verpackung

5 mL Amber Glass Screw Cap Vial (860819P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3