860815P

16:0(2R-OH) Ceramide

Avanti Research^™ - A Croda Brand 860815P, powder

• Synonym(e): N-(2′-(R)-hydroxypalmitoyl)-D-erythro-sphingosine
• Empirische Formel (Hill-System): C₃₄H₆₇NO₄
• CAS-Nummer: 34839-02-6
• Molekulargewicht: 553.90
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 25 mg (860815P-25mg); pkg of 1 × 5 mg (860815P-5mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 860815P
• Lipid-Typ: sphingolipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCC)=O)CO

Beschreibung

Allgemeine Beschreibung

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis. 16:0(2R-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in R configuration.

Biochem./physiol. Wirkung

Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling. They may also help in regulation of cell differentiation and apoptosis. Synthetic 2′R-hydroxy-C16-ceramide exhibits high proapoptotic activity than proapoptotic 2′S-hydroxy-C16-ceramide. hFA-ceramides in epidermis support permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes neurological disorders including, leukodystrophy and spastic paraparesis in humans. The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane.

Verpackung

5 mL Amber Glass Screw Cap Vial (860815P-25mg)

5 mL Amber Glass Screw Cap Vial (860815P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3