930598

VH032-OH

≥95%

• Synonym(e): (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-[2-hydroxy-4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide, L-Prolinamide, N-acetyl-3-methyl-L-valyl-4-hydroxy-N-[[2-hydroxy-4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• Empirische Formel (Hill-System): C₂₄H₃₂N₄O₅S
• CAS-Nummer: 2244684-42-0
• Molekulargewicht: 488.60
• UNSPSC Code: 12352101
• NACRES: NA.22
• MDL number: MFCD34368523

Eigenschaften

• ligand: VH032
• Quality Segment: 100
• assay: ≥95%
• form: powder
• reaction suitability: reagent type: ligand
• technique(s): targeted protein degradation: suitable
• functional group: hydroxyl
• storage temp.: 2-8°C

Beschreibung

Application

VH032-OH is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules


Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG


Small-Molecule PROTACS: New Approaches to Protein Degradation


Targeted Protein Degradation: from Chemical Biology to Drug Discovery


Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable