930237

2,5-dioxopyrrolidin-1-yl (2,5-dichlorobenzoyl)glycyl-L-leucinate

≥95%

• Synonym(e): CANDDY_MLN Tag NHS ester
• Empirische Formel (Hill-System): C₁₉H₂₁Cl₂N₃O₆
• Molekulargewicht: 458.29
• UNSPSC Code: 12352209
• NACRES: NA.21

Eigenschaften

• Quality Segment: 100
• assay: ≥95%
• form: powder
• storage temp.: 2-8°C
• SMILES string: ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1
• InChI: 1S/C19H21Cl2N3O6/c1-10(2)7-14(19(29)30-24-16(26)5-6-17(24)27)23-15(25)9-22-18(28)12-8-11(20)3-4-13(12)21/h3-4,8,10,14H,5-7,9H2,1-2H3,(H,22,28)(H,23,25)/t14-/m0/s1
• InChI key: KCUJPSDSTWVHLQ-AWEZNQCLSA-N

Beschreibung

Application

CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.

CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable