920657

3-(7-(tert-Butoxycarbonyl)-2-ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoic acid hydrochloride

• Synonym(e): Rigid linker for PROTAC^® development
• Empirische Formel (Hill-System): C₁₆H₂₆ClN₃O₄
• Molekulargewicht: 359.85
• UNSPSC Code: 12352106
• NACRES: NA.22

Eigenschaften

• form: powder and chunks
• Quality Segment: 100
• reaction suitability: reagent type: linker
• technique(s): targeted protein degradation: suitable
• functional group: Boc, carboxylic acid
• storage temp.: 2-8°C
• SMILES string: CCC1=C(CCC(O)=O)N2CCN(C(OC(C)(C)C)=O)CC2=N1.Cl
• InChI key: OYHWWEYTVJATKM-UHFFFAOYSA-N

Beschreibung

Application

3-(7-(tert-Butoxycarbonyl)-2-ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoic acid hydrochloride is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Other Notes

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Similar linkers in this series:
920568
920657
ENAH38A2CCD6
AC5372910424

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable