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Merck

918636

Sigma-Aldrich

Low endotoxin GelMA solution

gel strength 300 (bloom), degree of substitution 80%, 0.2 μm, sterile-filtered, GelMA Type B

Synonym(e):

GelMA, Gelatin methacrylamide, Gelatin methacrylate, Gelatin methacryloyl

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€ 480,00

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About This Item

UNSPSC-Code:
12352202
NACRES:
NA.23

€ 480,00


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Qualitätsniveau

Sterilität

sterile-filtered

Form

viscous liquid

Konzentration

20 wt. % in DPBS (buffer)

Verunreinigungen

≤5 CFU/g Bioburden (Fungal)
≤5 CFU/g Bioburden(Aerobic)
<25 EU/mL Endotoxin

Farbe

colorless to pale yellow

Partikelgröße

0.2 μm

pH-Wert

6.5-7.5

Lagertemp.

−20°C

Anwendung

Low endotoxin GelMA solution is a 20% low endotoxin gelatin methacrylate (GelMA) solution in DPBS buffer. It is sterile filtrated through 0.2 μm sterile filter, and ready to be used in biomedical applications.
GelMA can be used to form hydrogels for tissue engineering and 3D bioprinting. Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.

Verpackung

10 mL in glass bottle

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3


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Preparation and characterization of gelatin-poly(methacrylic acid) interpenetrating polymeric network hydrogels as a pH-sensitive delivery system for glipizide.
Gupta V N, et al.
Indian Journal of Pharmaceutical Sciences, 69(1), 64-68 (2007)
Kristel W M Boere et al.
Acta biomaterialia, 10(6), 2602-2611 (2014-03-05)
Hydrogels can provide a suitable environment for tissue formation by embedded cells, which makes them suitable for applications in regenerative medicine. However, hydrogels possess only limited mechanical strength, and must therefore be reinforced for applications in load-bearing conditions. In most
Xin Zhao et al.
Advanced healthcare materials, 5(1), 108-118 (2015-04-17)
Natural hydrogels are promising scaffolds to engineer epidermis. Currently, natural hydrogels used to support epidermal regeneration are mainly collagen- or gelatin-based, which mimic the natural dermal extracellular matrix but often suffer from insufficient and uncontrollable mechanical and degradation properties. In
Kelly M C Tsang et al.
Advanced functional materials, 25(6), 977-986 (2015-09-04)
Hydrogels are often employed as temporary platforms for cell proliferation and tissue organization in vitro. Researchers have incorporated photodegradable moieties into synthetic polymeric hydrogels as a means of achieving spatiotemporal control over material properties. In this study protein-based photodegradable hydrogels
Heemin Kang et al.
Acta biomaterialia, 10(12), 4961-4970 (2014-08-26)
Human induced pluripotent stem cells (hiPSC) are a promising cell source with pluripotency and self-renewal properties. Design of simple and robust biomaterials with an innate ability to induce lineage-specificity of hiPSC is desirable to realize their application in regenerative medicine.

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