907375

H-L-Photo-methionine HCl

≥95%

• Synonym(e): (S)-2-Amino-4-(3-methyl-3H-diazirin-3-yl)butanoic acid hydrochloride, (S)-2-Amino-4-(3H-diazirin-3-yl)pentanoic acid hydrochloride, Diazirine amino acid, Photo-Met, Photo-crosslinking amino acid, Photoprobe building block
• Empirische Formel (Hill-System): C₆H₁₂ClN₃O₂
• CAS-Nummer: 851960-68-4
• Molekulargewicht: 193.63
• UNSPSC Code: 12352209

Eigenschaften

• assay: ≥95%
• form: powder
• reaction suitability: reaction type: solution phase peptide synthesis
• availability: available only in USA
• application(s): peptide synthesis
• storage temp.: 2-8°C

Beschreibung

Application

H-L-Photo-Methionine HCl is a diazirine-containing methionine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (~360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907367.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Other Notes

Carboxyl-Photo-Reactive MS-Cleavable Cross-Linkers: Unveiling a Hidden Aspect of Diazirine-Based Reagents

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancer

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Sicherheitshinweise

• pictograms: GHS02
• signalword: Danger
• hcodes: H242
• pcodes: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Lagerklasse: 5.2 - Organic peroxides and self-reacting hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable