907367

Fmoc-L-photo-methionine

≥95%, for peptide synthesis

• Synonym(e): (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-(3-methyl-3H-diazirin-3-yl)butanoic acid, (S)-2-(Fmoc-amino)-4-(3H-diazirin-3-yl)pentanoic acid, Diazirine amino acid, Photo-Met, Photo-crosslinking amino acid, Photoprobe building block
• Empirische Formel (Hill-System): C₂₁H₂₁N₃O₄
• CAS-Nummer: 945859-89-2
• Molekulargewicht: 379.41
• MDL number: MFCD31380717
• UNSPSC Code: 12352209
• NACRES: NA.22

Eigenschaften

• Produktname: Fmoc-L-photo-methionine, ≥95%
• assay: ≥95%
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• application(s): peptide synthesis
• functional group: Fmoc
• storage temp.: −20°C
• SMILES string: N([C@@H](CCC4(N=N4)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI key: QKMQUEIDJLPYHS-SFHVURJKSA-N

Beschreibung

Application

Fmoc-L-photo-methionine is a diazirine-containing, Fmoc-protected methionine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907375.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Other Notes

Developing diazirine-based chemical probes to identify histone modification ′readers′ and ′erasers ′

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

Covalent Capture of Phospho-Dependent Protein Oligomerization by Site-Specific Incorporation of a Diazirine Photo-Cross-Linker

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable