764787

Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)

average M_n (1,000-1,000-1,000), lactide:glycolide 50:50

• Synonym(e): PLGA-PEG-PLGA
• NACRES: NA.23
• UNSPSC Code: 12162002

Eigenschaften

• description: typical PEG PDI<1.1; overall PDI<1.2 (THF, PEO)
• form: liquid
• feed ratio: lactide:glycolide 50:50
• mol wt: PEG average M_n 1,000, PLGA average M_n 2000, average M_n (1,000-1,000-1,000)
• degradation timeframe: 1-2 weeks
• PDI: <1.2
• storage temp.: 2-8°C

Beschreibung

General description

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.

Application

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.

Features and Benefits

Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Was ist los?: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable