SML2760
SGC6870
≥98% (HPLC)
Synonym(s):
(R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Size/SKU | Availability | Price |
|---|
About This Item
Empirical Formula (Hill Notation):
C23H21BrN2O2S
Molecular Weight:
469.39
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +260 to +300°, c = 0.5 in methanol
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Potent and selective protein arginine methyltransferase PRMT6 inhibitor.
SGC6870 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC50 = 77 nM by cell-free assays; IC50 = 0.8 μM against asymmetric H3R2 dimethylation of overexpressed PRMT6 in HEK293T cells) over all other PRMTs and 23 methyltransferases. The (S)-enantiomer SGC6870N is inactive toward PRMT6 and serves as an excellent control compound.
1 of 1
This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 15 mg/mL (clear solution) | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear |
| color white to beige | color white to beige | color white to beige | color white to beige |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.