E8031

Esmolol hydrochloride

≥98% (HPLC), solid

• Synonym(s): 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride hydrochloride
• Empirical Formula (Hill Notation): C₁₆H₂₆NClO₄
• CAS Number: 81161-17-3
• Molecular Weight: 331.83
• MDL number: MFCD00941432
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799075
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• mp: 89.0-90.6 °C
• solubility: H₂O: 12 mg/mL
• originator: Baxter
• storage temp.: 2-8°C
• SMILES string: Cl.COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1
• InChI: 1S/C16H25NO4.ClH/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3;/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3;1H
• InChI key: GEKNCWBANDDJJL-UHFFFAOYSA-N
• Gene Information: human ... ADRB1(153) , ADRB2(154)

Description

Application

Esmolol hydrochloride (ESM) may be used as a standard in spectrophotometric and electrochemical method for the determination of ESM in biological samples and pharmaceutical formulations.

Biochem/physiol Actions

Esmolol hydrochloride (ESM) is a class II antiarrhythmic drug. It is used to decrease the force and rate of heart contractions during surgery. Overdose of ESM can lead to side effects such as bradycardia, cardiac arrest, hypoventilation, mood disorder, and coma.

Esmolol hydrochloride is a ultrashort-acting β₁ adrenoceptor antagonist (β₁ receptor occupancy = 84.7%).

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves