8.51021

N₃-(PEG)₇-COOH (33 atoms)

Novabiochem^®

• Synonym(s): N₃-(PEG)₇-COOH (33 atoms), O-(2-Azidoethyl)-O′-(N-diglycolyl-2-aminoethyl)-heptaethyleneglycol
• Empirical Formula (Hill Notation): C₂₂H₄₂N₄O₁₂
• CAS Number: 846549-37-9
• Molecular Weight: 554.59
• MDL number: MFCD10001327
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• Quality Level: 400
• product line: Novabiochem^®
• Assay: ≥97.0% (HPLC)
• form: oil
• reaction suitability: reaction type: click chemistry
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• storage temp.: 2-8°C
• InChI: 1S/C22H42N4O12/c23-26-25-2-4-31-6-8-33-10-12-35-14-16-37-18-17-36-15-13-34-11-9-32-7-5-30-3-1-24-21(27)19-38-20-22(28)29/h1-20H2,(H,24,27)(H,28,29)
• InChI key: WWDNBBVPYDZICO-UHFFFAOYSA-N

Description

General description

This building block is prepared from highly purified PEG to ensure homogeneous products free from contaminating PEG oligomers. In this derivative the azido group acts as an orthogonally masked amine; it is stable to both TFA and piperidine but is easily converted to an amine by treatment with phosphines or thiols. For a similar spacer, see reference ^[1]. This material is now only available as an oil.

Associated Protocols and Technical Articles
Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS

Literature references
^[1] J. Mack, et al. (1999) J. Peptide Sci., 6, 135.

Linkage

Replaces: 01-63-0103

Analysis Note

Color (visual): slight yellow to yellow
Appearance of substance (visual): oil
Assay (HPLC, area%): ≥ 97.0 % (a/a)

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable