T7204

Toremifene citrate salt

≥98% (HPLC)

• Sinónimos: (Z)-2-(4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine, Acapodene, Fareston, GTx 006, Z-Toremifene
• Fórmula empírica (notación de Hill): C₂₆H₂₈ClNO · C₆H₈O₇
• Número de CAS: 89778-27-8
• Peso molecular: 598.08
• Número MDL: MFCD01729016
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 329826860
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to off-white
• solubilidad: DMSO: >10 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)CCOc1ccc(cc1)C(=C(\CCCl)c2ccccc2)\c3ccccc3
• InChI: 1S/C26H28ClNO.C6H8O7/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-16H,17-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
• Clave InChI: IWEQQRMGNVVKQW-OQKDUQJOSA-N
• Información sobre el gen: human ... ESR1(2099) , ESR2(2100)

Descripción

Descripción general

Toremifene is a triphenylethylene derivative.[1] It exhibits antitumor and antiestrogen effects.[2] Toremifene has estrogen-agonist effects on blood lipids and endometrium.[3]

Aplicación

Toremifene citrate salt has been used:

• in cell-based ELISA[4]
• as a positive control to detect its antiviral activity against Ebola virus (EBOV)[5]
• to treat MCF7 and T47D breast cancer cell lines[6]

Acciones bioquímicas o fisiológicas

Toremifene citrate is an oral selective estrogen receptor modulator (SERM). It is used in advanced (metastatic) breast cancer and being evaluated for prevention of prostate cancer. Toremifene citrate is known to increase bone mineral density in prostate cancer patients undergoing androgen deprivation therapy†.

Características y beneficios

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

Toremifene citrate salt is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Información de seguridad

• Pictogramas: GHS05,GHS07,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H302,H318,H410
• Consejos de prudencia: P264 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P391
• Clasificaciones de peligro: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable