T3309
Transferrina human
≥98%
Sinónimos:
Siderofilina parcialmente saturada
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About This Item
Productos recomendados
biological source
human
Quality Level
assay
≥98%
form
powder
Iron content
300-600 ppm
technique(s)
cell culture | stem cell: suitable
impurities
≤1.0 EU/mg endotoxin
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... TF(7018)
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General description
Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.
Application
Transferrin has been used:
- in isolation of epidermal stem cells and cell expansion
- to study the effect of compound treatment on transferrin uptake
- for transferrin uptake and confocal imaging
Biochem/physiol Actions
Transferrin facilitates the transfer of iron to erythron and peripheral tissues. Mutations in this gene is associated with atransferrinemia. Transferrin is required for fetal development. It is non immunogenic and transferrin-conjugated drugs inhibits cardiotoxicity and drug resistance.
Transferrin was shown to promote the proliferation of human lymphocytes. This effect is directly proportional to the level of iron present.
Analysis Note
Pureza por electroforesis en agarosa.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
TFRC (transferrin receptor (p90, CD71))
Dorak MT
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2009)
Severe hypochromic microcytic anemia in a patient with congenital atransferrinemia
Shamsian BS, et al.
Pediatric Hematology and Oncology, 26(5), 356-362 (2009)
A Djeha et al.
British journal of haematology, 80(2), 235-241 (1992-02-01)
The effect of different forms of iron and iron-binding proteins on the proliferative response of human lymphocytes to phytohaemagglutinin (PHA) has been studied. Transferrin enhanced proliferation, the effect being proportional to the degree of iron saturation up to 100%, but
Non-invasive in vivo imaging of near infrared-labeled transferrin in breast cancer cells and tumors using fluorescence lifetime FRET
Abe K, et al.
PLoS ONE, 8(11), e80269-e80269 (2013)
Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis
Tolosano E
The Hematology Journal : The Official Journal of the European Haematology Association / EHA (2015)
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