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SML2193

Sigma-Aldrich

Altenusin

≥98% (HPLC)

Sinónimos:

3,4′,5′-Trihydroxy-5-methoxy-2′-methyl[1,1′-biphenyl]-2-carboxylic acid, Alutenusin

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About This Item

Fórmula empírica (notación de Hill):
C15H14O6
Número de CAS:
31186-12-6
Peso molecular:
290.27
UNSPSC Code:
12352200
NACRES:
NA.77

biological source

Penicillium sp.

assay

≥98% (HPLC)

form

powder

color

yellow to orange

storage temp.

−20°C

SMILES string

OC1=CC(C2=CC(OC)=CC(O)=C2C(O)=O)=C(C)C=C1O

InChI

1S/C15H14O6/c1-8-5-13(16)14(17)7-11(8)12-6-9(20-2)3-4-10(12)15(18)21-19/h3-7,16-17,19H,1-2H3

InChI key

GWGIZSANXIQQQR-UHFFFAOYSA-N

Biochem/physiol Actions

Altenusin, a non-steroidal fungal metabolite, is a potent and selective agonist of Farnesoid X receptor (FXR) that protects mice from high-fat diet induced obesity. Also it decreases blood glucose level, serum insulin level, and reduces lipid droplets accumulation. Altenusin inhibits trypanothione reductase from Trypanosoma cruzi.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Betania Barros Cota et al.
FEMS microbiology letters, 285(2), 177-182 (2008-06-19)
Parasitic protozoan species belonging to the genera Trypanosoma and Leishmania are the etiological agents of several diseases in tropical areas of the world, for which there is an urgent need for effective and affordable treatment. In this regard, we are
Sook Wern Chua et al.
ACS chemical neuroscience, 8(4), 743-751 (2017-01-10)
In Alzheimer's disease, the microtubule-associated protein tau forms intracellular neurofibrillary tangles (NFTs). A critical step in the formation of NFTs is the conversion of soluble tau into insoluble filaments. Accordingly, a current therapeutic strategy in clinical trials is aimed at
Christian M Garrido et al.
Scientific reports, 10(1), 9120-9120 (2020-06-06)
K-Ras must interact primarily with the plasma membrane (PM) for its biological activity. Therefore, disrupting K-Ras PM interaction is a tractable approach to block oncogenic K-Ras activity. Here, we found that avicin G, a family of natural plant-derived triterpenoid saponins
Zhihui Zheng et al.
Molecular pharmacology, 92(4), 425-436 (2017-07-26)
Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. The incidence of NAFLD has increased steadily due to its close association with the global epidemic of obesity and type 2 diabetes. However, there is no effective pharmacological therapy
Jian Shi et al.
Cell reports, 33(1), 108225-108225 (2020-10-08)
Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines. Because prior work showed that the force of shear stress activates sphingomyelinase in endothelium, we considered if sphingomyelinase is relevant

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