Stock solutions of Resiquimod in DMSO or ethanol may be stored at -20°C for a maximum duration of 2 months.
SML0196
Resiquimod
≥98% (HPLC), powder, TLR7/TLR8 agonist
Sinónimos:
4-Amino-2-(ethoxymethyl)-alpha, R-848, R848, S28463, alpha-dimethyl-1H-imidazo(4,5-c)quinoline-1-ethanol
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10 MG
US$ 322,00
50 MG
US$ 634,00
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10 MG
US$ 322,00
50 MG
US$ 634,00
About This Item
Fórmula empírica (notación de Hill):
C17H22N4O2
Número de CAS:
Peso molecular:
314.38
Número MDL:
Código UNSPSC:
51111800
ID de la sustancia en PubChem:
NACRES:
NA.77
Productos recomendados
Nombre del producto
Resiquimod, ≥98% (HPLC)
Ensayo
≥98% (HPLC)
Formulario
powder
condiciones de almacenamiento
desiccated
protect from light
color
white to tan
solubilidad
DMSO: 10 mg/mL, clear (warmed to 60 °C)
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
cadena SMILES
CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
InChI
1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)
Clave InChI
BXNMTOQRYBFHNZ-UHFFFAOYSA-N
Aplicación
Resiquimod has been used in the stimulation of bone marrow-derived dendritic cells (BMDCs) stimulation([1] and B cells.[2] It has also been used as a ligand for toll-like receptors (TLR7) in malignant melanoma cell line B16F10.[3][4]
Resiquimod may be used in immunological and cancer-related cell signaling studies.
Acciones bioquímicas o fisiológicas
Resiquimod (R-848) is a potent synthetic agonist of TLR7/TLR8 that possesses antiviral and antitumoral activities.
Resiquimod belongs to the class of imidazoquinolinamines compounds with immunomodulatory effects. Resiquimod increases the levels of cytokines such as TNF-α, IL-6 and IFN-α.[5][6]
Resiquimod is 314.4 Da molecule which elicits immune function during visceral infection with L. infantum Sp. It mediates the trafficking of granulocytes, macrophages, leukocytes and dendritic cells.[7] It is a recommended topical drug for treating skin tumors like actinic keratosis (AK) and superficial basal cell carcinoma.[8]
Resiquimod is an agonist of toll-like receptor 7 and 8 (TLR- and TLR-8).
Características y beneficios
This compound is featured on the Cytokine Receptors (Interleukin-1 Receptor/TIR Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Artículos
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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